Hi Igor,
Unfortunately it isn't possible to edit the running-config, upload it, and make the changes take effect on the fly. If you upload a startup-config, the switch will reload.
On the 5300 series you can make changes to ACL's within the running-config with the 'copy command-file' option, but this is limited to ACL commands only.
Your best bet is to use ProCurve Manager Plus which has a CLI wizard feature. It should allow you to achieve what you're after.
Matt